Tetramethylguanidine-functionalized silica-coated iron oxide magnetic nanoparticles catalyzed one-pot three-component synthesis of furanone derivatives

Tetramethylguanidine-functionalized silica-coated iron oxide magnetic nanoparticles as a productive and reusable catalyst have been applied for the one-pot three-component synthesis of furanone derivatives (4a-o). In addition to the characterization of all products by FT-IR, 1HNMR and 13CNMR spectroscopy, single-crystal X-ray analysis of ethyl 5-oxo-2-phenyl-4-(phenylamino)-2,5-dihydrofuran-3carboxylate product has been made. Easy recrystallization and good-to-excellent yields (81-92%) of furanone derivatives are notable characteristics of this procedure. The catalyst identification was performed using FT-IR, XRD, SEM, TEM and TGA techniques. It is worth noting that the nanocatalyst can be recycled with an external magnet and reused for several times.