期刊
CARIES RESEARCH
卷 52, 期 1-2, 页码 14-21出版社
KARGER
DOI: 10.1159/000481832
关键词
Antibacterial material; Bonding system; Dimethylaminododecyl methacrylate; Keyes animal model; Micro-CT; Tooth restoration
资金
- National Key Research and Development Program of China [2016YFC1102700]
- National Natural Science Foundation of China [81372889, 81600858, 81372890, 81430011]
- Open Fund of State Key Laboratory of Oral Diseases [2040305193002]
- Recruitment Program for Young Professionals
- NIH [R01 DE17974]
- University of Maryland School of Dentistry bridging fund
- University of Maryland seed grant
We investigated the anticaries properties of an ad-hesive containing dimethylaminododecyl methacrylate (DMADDM) in vivo via a secondary caries animal model. Cavities were prepared in the maxillary first molars of Wistar rats. DMADDM-containing adhesives were applied on one side and commercial adhesives on the opposite side as a control. After a 3-week feeding period to induce secondary caries, the molars were harvested for the evaluation of the secondary caries. Lesion depth (LD) and mineral loss (ML) were measured via a micro-CT method, and a modified Keyes scoring method yielded scores for the caries lesions. Statistical analysis was divided into 2 parts: a correlation analysis between 2 evaluations with one-way ANOVA and a least-significant differences (LSD) test, and an evaluation of anticaries adhesives with a paired samples t test. The results showed that: 1) secondary caries was successfully produced in rats; (2) there was a correlation between the modified Keyes scoring method and micro-CT in the evaluation of the secondary caries; (3) the adhesive containing DMADDM significantly reduced both LD and ML (according to micro-CT), and also lowered the scores (based on the modified Keyes scoring method). This suggests that the novel DMADDM adhesive could perform an anticaries function in vivo via the secondary caries animal model which was also developed and testified in research. Secondary caries is one of the major reasons leading to the failure of caries restoration treatment. As a solution, anticaries adhesives perform well in biofilm inhibition in vitro. However, the lack of secondary caries animal models limits the evaluation of anticaries adhesives in vivo. (C) 2017 The Author(s) Published by S. Karger AG, Basel
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