期刊
NATURE CATALYSIS
卷 1, 期 6, 页码 429-437出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41929-018-0081-x
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资金
- EPSRC through the EPSRC Centre for Doctoral Training in Catalysis [EP/K012258/1]
- AstraZeneca
- EPSRC
- Engineering and Physical Sciences Research Council [EP/K03927X/1] Funding Source: researchfish
- EPSRC [EP/K03927X/1, EP/K012258/1, EP/L022532/1] Funding Source: UKRI
Although the replacement of ubiquitous palladium catalysts with more sustainable iron-based analogues continues apace, the simple biaryl Suzuki cross-coupling reaction remains stubbornly elusive. It appears that the main issue hampering the reaction is activation of the aryl halide C-X bond. Here we show that a simple N-pyrrole amide and related directing groups on the aryl halide substrates facilitate this process by transient pi-coordination to the iron centre. This allows iron-catalysed Suzuki biaryl cross-coupling to proceed, under mild conditions, with alkyllithium-activated aryl pinacol boronic esters.
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