Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction

Herein, we report the preparation of 1,2,4-thiadiazinane 1,1-dioxides from reaction of beta-aminoethane sulfonamides with dichloromethane, dibromomethane and formaldehyde as methylene donors. The beta-aminoethane sulfonamides were obtained through sequential Michael addition of amines to alpha,beta-unsaturated ethenesulfonyl fluorides followed by further DBU mediated sulfur(vi) fluoride exchange (SuFEx) reaction with amines at the S-F bond.