期刊
NATURE CATALYSIS
卷 1, 期 11, 页码 860-869出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41929-018-0147-9
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资金
- National Natural Science Foundation of China [2167020084]
- 'Jiangsu Specially-Appointed Professor Plan' of Jiangsu Province
- 'Innovation and Entrepreneurship Talents Plan' of Jiangsu Province
- Funding Programs for the '1000 Youth Talents Plan'
Multi-borylated compounds are useful starting materials for the construction of complex molecules. Although certain classes of multi-borylated compounds, such as geminal and 1,2-bis(boronates), can now be accessed selectively by several well-established methods, the synthesis of one class-those containing more than two boronate substituents-remains a great challenge. Here, copper catalytic systems were developed for the borylation of gem-difluoroalkenes with B(2)pin(2) via dual C-F bond activation to afford multi-borylate libraries-1,2-alkyldiboronates, 1,1,2-alkyltriboronates and 1,1,1,2-alkyltetraboronates-by slightly tuning the reaction conditions. The advantages of this strategy include not only avoiding the use of different methods and substrates for each type of multi-substituted alkyl boronate, but also the excellent functional group compatibility, readily accessible gem-difluorovinyl group and highly chemoselective process.
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