期刊
ENDOCRINOLOGY
卷 156, 期 2, 页码 589-599出版社
OXFORD UNIV PRESS INC
DOI: 10.1210/en.2014-1204
关键词
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资金
- National Natural Science Foundation of China [31372512, 31172394, 31325026]
- Research Grant Council of Hong Kong [463013]
The kiss1/gpr54 signaling system is considered to be a critical regulator of reproduction in most vertebrates. However, this presumption has not been tested vigorously in nonmammalian vertebrates. Distinct from mammals, multiple kiss1/gpr54 paralogous genes (kiss/kissr) have been identified in nonmammalian vertebrates, raising the possibility of functional redundancy among these genes. In this study, we have systematically generated the zebrafish kiss1(-/-), kiss2(-/-), and kiss1(-/-); kiss2-/- mutant lines as well as the kissr1(-/-), kissr2(-/-), and kissr1(-/-); kissr2(-/-) mutant lines using transcription activator-like effector nucleases. We have demonstrated that spermatogenesis and folliculogenesis as well as reproductive capability are not impaired in all of these 6 mutant lines. Collectively, our results indicate that kiss/kissr signaling is not absolutely required for zebrafish reproduction, suggesting that the kiss/kissr systems play nonessential roles for reproduction in certain nonmammalian vertebrates. These findings also demonstrated that fish and mammals have evolved different strategies for neuroendocrine control of reproduction.
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