期刊
SYNTHETIC COMMUNICATIONS
卷 48, 期 18, 页码 2339-2346出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2018.1480041
关键词
3-Furano-chromone; 4-furano-coumarin; antitubercular activity; C-H; C-H functionalization
资金
- University of Delhi
- DRDO
- CSIR
The synthesis of novel 4-furano-coumarins and 3-furano-chromones has been achieved using silver-mediated oxidative C-H/C-H functionalization of 4-ethynylcoumarin/3-ethynylchromone with ethyl acetoacetate in 80%-90% and 82%-90% yields, respectively. The structure of the synthesized compounds was established on the basis of their spectral data analysis and the structure of one of the 4-furano-coumarins has been further confirmed on the basis of its X-ray crystallographic study. All eight synthesized 4-furano-coumarins and 3-furano-chromones exhibited moderate antitubercular activity against sensitive reference strain H37Rv of Mycobacterium tuberculosis. [GRAPHICS] .
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