期刊
ANNALS OF THE AMERICAN THORACIC SOCIETY
卷 15, 期 4, 页码 440-448出版社
AMER THORACIC SOC
DOI: 10.1513/AnnalsATS.201706-451OC
关键词
respiratory function tests; ciliary motility disorders; cystic fibrosis; genetic association studies
资金
- Cystic Fibrosis Foundation [GIBSON07K0, KNOWLE00A0, OBSERV04K0]
- National Heart, Lung, and Blood Institute (NHLBI)
- NHLBI [RC2 HL-103010, RC2 HL-102923, RC2 HL-102924, RC2 HL-102925, RC2 HL-102926]
- National Institutes of Health grants National Library of Medicine (NLM) [K22LM011938]
- NIGMS [R01GM114128]
- NCATS [UL1TR000427]
Rationale: Cystic fibrosis, like primary ciliary dyskinesia, is an autosomal recessive disorder characterized by abnormal mucociliary clearance and obstructive lung disease. We hypothesized that genes underlying the development or function of cilia may modify lung disease severity in persons with cystic fibrosis. Objectives: To test this hypothesis, we compared variants in 93 candidate genes in both upper and lower tertiles of lung function in a large cohort of children and adults with cystic fibrosis with those of a population control dataset. Methods: Variants within candidate genes were tested for association using the SKAT-O test, comparing cystic fibrosis cases defined by poor (n = 127) or preserved (n = 127) lung function with population controls (n = 3,269 or 3,148, respectively). Associated variants were then tested for association with related phenotypes in independent datasets. Results: Variants in DNAH14 and DNAAF3 were associated with poor lung function in cystic fibrosis, whereas variants in DNAH14 and DNAH6 were associated with preserved lung function in cystic fibrosis. Associations between DNAH14 and lung function were replicated in disease-related phenotypes characterized by obstructive lung disease in adults. Conclusions: Genetic variants within DNAH6, DNAH14, and DNAAF3 are associated with variation in lung function among persons with cystic fibrosis.
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