期刊
CEREBRAL CORTEX
卷 28, 期 4, 页码 1383-1395出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhx335
关键词
Antidepressant; Functional Connectivity; Graph Theory; MDD; Resting-state fMRI
资金
- National Basic Research (973) Program [2015CB351702]
- Natural Science Foundation of China [NSFC 31271189, 81471740]
- Beijing Municipal Science and Tech Commission [Z161100002616023, Z171100000117012]
- China - Netherlands CAS-NWO Programme [153111KYSB20160020]
- Major Project of National Social Science Foundation of China [14ZDB161]
- NSFC Major Joint Fund for International Cooperation and Exchange [81220108014]
- National Institutes of Health [R01AR009036]
- National R&D Infrastructure and Facility Development Program of China, Fundamental Science Data Sharing Platform [DKA2017-12-02-21]
Major depressive disorder (MDD) is known to be associated with altered interactions between distributed brain regions. How these regional changes relate to the reorganization of cortical functional systems, and their modulation by antidepressant medication, is relatively unexplored. To identify changes in the community structure of cortical functional networks in MDD, we performed a multiscale community detection algorithm on resting-state functional connectivity networks of unmedicated MDD (uMDD) patients (n = 46), medicated MDD (mMDD) patients (n = 38), and healthy controls (n = 50), which yielded a spectrum of multiscale community partitions. we selected an optimal resolution level by identifying the most stable community partition for each group. uMDD and mMDD groups exhibited a similar reconfiguration of the community structure of the visual association and the default mode systems but showed different reconfiguration profiles in the frontoparietal control (FPC) subsystems. Furthermore, the central system (somatomotor/salience) and 3 frontoparietal subsystems showed strengthened connectivity with other communities in uMDD but, with the exception of 1 frontoparietal subsystem, returned to control levels in mMDD. These findings provide evidence for reconfiguration of specific cortical functional systems associated with MDD, as well as potential effects of medication in restoring disease-related network alterations, especially those of the FPC system.
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