期刊
ELECTROANALYSIS
卷 30, 期 4, 页码 641-649出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201700638
关键词
electrochemical sensor; voltammtetry; tryptophan determination; silver nanoparticles; polymer film
资金
- Russian Science Foundation [16-13-00005]
- Russian Science Foundation [16-13-00005] Funding Source: Russian Science Foundation
Glassy carbon electrode (GCE) was modified by new polymeric materials obtained from oligolactides by cross-linking with tetracarboxylated thiacalix[4]arene in cone, partial cone and 1,3-alternate configurations and then silver was deposited by potential cycling in the pores of the polymer film. The modified electrode showed highly sensitive and selective signal toward tryptophan which was irreversibly oxidized on the coating due to Ag+ assisted accumulation in the surface layer. The role of macrocycle configuration and conditions for Ag nanodendrites formation are described. Granulation of the polymer films caused by the macrocycles improves both the conditions for silver deposition and tryptophan determination. The electrochemical sensor developed makes it possible to determine from 0.1 to 100M of tryptophan with the limit of detection down to 0.03M. No interference with oxidation of other amino acids (phenylalanine, histidine, cysteine and tyrosine) was found. The electrochemical sensor developed was validated in the determination of tryptophan sedative medication Formula of calmness in the presence of vitamins B-5 and B-6.
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