Facile synthesis of unnatural -germyl--amino amides via Pd(ii)-catalyzed primary and secondary C(sp3)-H bond germylation

Pd(ii)-Catalyzed direct C(sp(3))-H germylation of -AA derivatives with the assistance of a bidentate auxiliary for the efficient synthesis of -germyl--amino amides is reported. This protocol features good generality for primary and secondary C-H bonds of aliphatic amides. Mechanistic studies show that a crucial five-membered palladacycle intermediate may play a key role in this process.