期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 100, 页码 14065-14068出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc07990k
关键词
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资金
- National Natural Science Foundation of China [21372091]
- Research Funds for the Central Universities [CCNU18TS2041]
- 111 Project [B17019]
Herein, we described photoenzymatic dynamic kinetic resolution (DKR) of amines under mild conditions. The racemization of amines via a photoredox-mediated hydrogen atom transfer (HAT) protocol in conjunction with an enzyme catalyst to achieve the DKR of amines allows a variety of primary amines to be converted into a single enantiomer in high yield and with excellent enantioselectivity. Notably, this protocol can also be extended to 1,4-diamine derivatives with high levels of diastereo-and enantioselectivity.
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