期刊
NEW JOURNAL OF CHEMISTRY
卷 41, 期 10, 页码 3723-3731出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nj00379j
关键词
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资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 480719/2012-8, 474797/2013-9, PVE 401193/2014-4, PQ-SR CNPq 302613/2013-7]
- FAPEMIG [01/2014]
- Programa Pesquisador Mineiro
- CAPES
- FAPERJ
- CAPES/PROCAD
- PAPES/Fiocruz
Phenazinic ligands and Ru(II)-based complexes were synthesized from natural products lapachol and lawsone and evaluated against T. cruzi, the etiological agent of Chagas disease. These new ruthenium compounds could provide promising trypanocidal drugs. Besides synthesis and trypanocidal activity, this paper reports photophysical features and computational details of the compounds. The fluorescent trypanocidal substances are promising derivatives for further studies aiming to find molecules active against parasites associated with neglected diseases.
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