期刊
SCANDINAVIAN JOURNAL OF UROLOGY
卷 52, 期 4, 页码 302-308出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21681805.2018.1505945
关键词
Fibrosis; germinal centre formation; histopathology; inflammation; sclerosis; urethral stricture; urethroplasty
资金
- Anna-Lisa and Bror Bjornssons Foundation
- Marta and Gustaf Agren's Research Foundation
- ALF/LUA research grants from Gothenburg University
Objective: The aim of this study was to assess whether sclerosis in histology following bulbar urethroplasty is a predictive factor for failure of surgery. Materials and methods: Resected stricture specimens from 45 patients undergoing open urethroplasty with excision and anastomosis were collected prospectively during 2011-2014. Histopathological characteristics, including fibrosis (grade I-III), inflammation and sclerosis, were evaluated using different routine staining. These specimens were compared to normal urethral resection specimens from patients undergoing sex-correction surgery. The uropathologist who conducted the analyses was blinded to the study design. Results: The outcomes of the histological classifications were as follows: 19 patients had grade I fibrosis, of whom three had failures; 13 patients had grade II fibrosis, without any failures; and the most severe fibrosis, grade III, including sclerosis, was found in 13 patients (11 with sclerosis), with failure in eight. Sclerosis was a significant risk factor for restricture when comparing patients with sclerosis and those without sclerosis, and likewise when adjusting for age, inflammation and stricture length. Conclusion: Histological findings of sclerosis in the resected urethral stricture specimen indicate a significantly higher risk for restricture after urethroplasty surgery.
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