期刊
NEW JOURNAL OF CHEMISTRY
卷 41, 期 3, 页码 1082-1093出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nj03210a
关键词
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资金
- Department of Science and Technology (DST)
- Council of Scientific and Industrial Research (CSIR) New Delhi, India
- DST [CS-361/2011]
- DST-FIST [CSI-228/2011]
- CSIR, New Delhi [02(0202)/14/EMR-II]
- TEQIP-II, NIT Jalandhar
Synthesis of beta-carboline based natural products and synthetic derivatives is one of the frontier areas of research owing to their medicinal properties. It is envisaged that 3-formyl-9H-beta-carboline is a potential precursor and offers new vistas for the construction of a variety of heterocyclic architectures at the C-3 position of the beta-carboline skeleton. In this context, an efficient protocol has been developed for the synthesis of beta-carboline C-3 tethered imidazo[1,2-a] pyridine, imidazo[1,2-a] pyrimidine, and imidazo[1,2-a]pyrazine derivatives via exploration of the Groebke-Blackburn-Bienayme (GBB) reaction. The present protocol offers several advantages like operational simplicity, high atom economy, appreciable structural diversity and easy purification procedure.
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