Hydrocortisone, Vitamin C and thiamine for the treatment of sepsis and septic shock following cardiac surgery

Background and Aims: The effect of vitamin Con vasopressor requirement in critically ill patients have been evaluated previously. We aimed to evaluate the effect of vitamin C, hydrocortisone and thiamine on vasopressor requirement and mortality in post-operative adult cardiac surgical patients with septic shock. Methods: About 24 patients with septic shock were randomised into Group 1 (receiving matching placebo per day for 4 days) and Group 2 (receiving 6 g vitamin C, 400 mg thiamine and 200 mg hydrocortisone per day for 4 days). Vasopressor dose over 4 days of therapy was the primary endpoint, whereas in-hospital mortality was the secondary endpoint. Results: APACHE IV and EUROSCORE II scores were similar between both the groups. Significant reductions in the requirement of vasopressin (difference from day 1 - 0.0008 +/- 0.00289 vs 0.0033 +/- 0.00492 units/kg/min: P= 0.019) and noradrenaline (difference from day 1 -0.0283 +/- 0.040 vs 0.023 +/- 0.035 mu g/kg/min: P= 0.006) were observed with vitamin C treatment as compared to control group. PCT levels on Day 3 (68.11 +/- 33.64 vs 33.2 +/- 27.55 ng/mL; P= 0.0161) and Day 4 (70.03 +/- 29.74 vs 26.3 +/- 23.08 ng/mL; P= 0.0009) were significantly lower in treatment group as compared to control. However, there was no difference in the Sepsis-Related Organ Failure Assessment (SOFA) score and mortality between the studied groups. Conclusion: Combination of vitamin C, thiamine and hydrocortisone reduces vasopressor requirement in adult cardiac surgical patients with septic shock.