期刊
FOOD & FUNCTION
卷 9, 期 12, 页码 6338-6349出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8fo01117f
关键词
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资金
- National Key R & D Program of China [2016YFD0400303]
- Natural Science Foundation of Guangdong Province [2017A030311021]
- Guangdong Province R D Program [2012B020312002]
Here, the antioxidant and hypoglycemic activities of polysaccharides from Huidouba were preliminarily characterized. Two novel polysaccharides, HDBP-1 and HDBP-2 (127.33 kDa and 9.703 kDa, respectively), were purified by ultrafiltration using a Sephadex G-200 column and then characterized by high-performance gel permeation chromatography (HPGPC), high-performance liquid chromatography (HPLC), infrared spectroscopy (FT-IR), GC-MS, NMR and the Congo red test. HDBPs (crude Huidouba polysaccharide (CHDBP), HDBP-1 and HDBP-2) exhibited significant antioxidant and -glucosidase inhibitory activities in vitro. In addition, in vivo hypoglycemia experiments in mice revealed that CHDBP, HDBP-1 and HDBP-2 demonstrated active roles in reversing diabetic symptoms. These polysaccharides decreased the serum triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels and significantly improved oral glucose tolerance (OGT), indicating that HDBPs suppressed obesity and alleviated insulin resistance. Moreover, HDBP-2 with lower molecular weight performed better in antioxidant capacity, -glucosidase-inhibiting activity and hypoglycemic activity. These results suggest that HDBPs have the potential to be functional foods with hypoglycemic properties.
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