期刊
NEW BIOTECHNOLOGY
卷 34, 期 -, 页码 32-39出版社
ELSEVIER
DOI: 10.1016/j.nbt.2016.10.004
关键词
1,3-propanediol; 3-hydroxypropionic acid; Glycerol utilization; Lactobacillus diolivorans
资金
- Christian Doppler Research Association
- Vogelbusch GmbH, Vienna, Austria
This study investigates potential limitations of 1,3-propanediol formation by Lactobacillus diolivorans. Particular focus is given to enhanced glycerol utilization as well as the elimination of by-product formation. The key aspect is a modulation of the redox household by process engineering through the application of carbon pulses. A shift in the product pattern of C3 products was achieved, improving the ratio of 1,3-propanediol versus 3-hydroxypropionic acid up to a level of 20:1. Moreover, in combination with alternative feeding strategies this ratio was enhanced up to 45:1 and the maximum observed productivity of 1,3-propanediol could be significantly increased to 1.7 g/Lh. (C) 2016 Elsevier B.V. All rights reserved.
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