期刊
NEUROTOXICOLOGY AND TERATOLOGY
卷 60, 期 -, 页码 59-62出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ntt.2016.11.004
关键词
Anesthesia; Anesthetics; Autophagy; Calcium; Apoptosis; Neurodegeneration
资金
- NIH [K08-GM073224, R01GM084979, 3R01GM084979-0251, 2R01GM084979-06A1]
- March of Dimes Birth Defects Foundation [12-FY08-167]
- Department of Anaesthesiology, Perelman School of Medicine, University of Pennsylvania
A number of findings suggested that general anesthetics induced neural cell death by apoptosis in various animal models. Although clinical evidence regarding the correlation between anesthetic exposures at young age and subsequent cognitive impairments remains unclear, repeated or consistent exposures to general anesthetics may be a potential harmful risk in developing human brains. The mechanisms underlying the anesthetic neurotoxicity have received extensive attention recently. We will attempt a brief review to summarize current understanding on the role of both apoptosis and autophagic cell death mediated by calcium dysregulation in anesthetic neurotoxicity. (C) 2016 Elsevier Inc. All rights reserved.
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