期刊
NEUROTOXICOLOGY
卷 58, 期 -, 页码 103-109出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.neuro.2016.11.006
关键词
Parkinson's disease; Non-motor symptoms; Rotenone; Zebrafish
资金
- Suzhou Clinical Research Center of Neurological Disease [Szzx201503]
- National Natural Science Foundation of China [81471299]
- Jiangsu Provincial Special Program of Medical Science [BL2014042]
- Suzhou Clinical Key Disease Diagnosis and Treatment Technology Foundation [LCZX201304]
- Plans for Graduate Research and Innovation in Colleges and Universities of Jiangsu Province [KYZZ15_0334]
- Suzhou Medical Key Discipline Project
- Priority Academic Program Development of Jiangsu Higher Education Institutions
The pesticide rotenone is widely used to produce Parkinson's disease (PD)-like symptoms in rodents, but few studies have examined whether rotenone-treated zebrafish can serve as an animal model of PD. Here, we report that 4 weeks of rotenone treatment induced motor and non-motor PD-like symptoms in adult zebrafish. Compared with control fish, rotenone-treated fish spent less time swimming at a fast speed, indicating a deficit in motor function. In the light-dark box test, rotenone-treated fish exhibited longer latencies to enter the dark compartment and spent more time in the light compartment, reflecting anxiety- and depression-like behavior. Furthermore, rotenone-treated fish showed less of an olfactory preference for amino acid, indicating olfactory dysfunction. These behavioral symptoms were associated with decreased levels of dopamine in the brains of rotenone-treated fish. Taken together, these results suggest that rotenone-treated zebrafish are a suitable model of PD. (C) 2016 Elsevier B.V. All rights reserved.
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