期刊
NEUROTHERAPEUTICS
卷 15, 期 1, 页码 109-125出版社
SPRINGER
DOI: 10.1007/s13311-017-0588-x
关键词
Multiple sclerosis (MS); gutmicrobiome; immune response; experimental autoimmune encephalomyelitis (EAE); host-microbe interaction; microbial metabolism
资金
- National Multiple Sclerosis Society [RG 5138A1/1T]
- Carver College of Medicine at the University of Iowa (pathology pilot grant)
- Carver Trust Medical Research Initiative Grant
- Mayo Clinic Center for Individualized Medicine
- [T32AI007485]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007485] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES005605] Funding Source: NIH RePORTER
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system with unknown etiology. Recently, the gut microbiota has emerged as a potential factor in the development of MS, with a number of studies having shown that patients with MS exhibit gut dysbiosis. The gut microbiota helps the host remain healthy by regulating various functions, including food metabolism, energy homeostasis, maintenance of the intestinal barrier, inhibition of colonization by pathogenic organisms, and shaping of both mucosal and systemic immune responses. Alteration of the gut microbiota, and subsequent changes in its metabolic network that perturb this homeostasis, may lead to intestinal and systemic disorders such as MS. Here we discuss the findings of recent MS microbiome studies and potential mechanisms through which gut microbiota can predispose to, or protect against, MS. These findings highlight the need of an improved understanding of the interactions between the microbiota and host for developing therapies based on gut commensals with which to treat MS.
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