期刊
NEUROSURGICAL FOCUS
卷 42, 期 4, 页码 -出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2017.1.FOCUS16497
关键词
neuroprotection; acute ischemic stroke; free radical; excitotoxicity; immune
资金
- WSU Neurosurgery Fund
- American Heart Association [14GRNT20460246]
- Merit Review Award from the US Department of Veterans Affairs Rehabilitation RD Service [I01RX-001964-01]
Acute ischemic stroke (AIS) is a leading cause of disability and death worldwide. To date, intravenous tissue plasminogen activator and mechanical thrombectomy have been standards of care for AIS. There have been many advances in diagnostic imaging and endovascular devices for AIS; however, most neuroprotective therapies seem to remain largely in the preclinical phase. While many neuroprotective therapies have been identified in experimental models, none are currently used routinely to treat stroke patients. This review seeks to summarize clinical studies pertaining to neuroprotection, as well as the different preclinical neuroprotective therapies, their presumed mechanisms of action, and their future applications in stroke patients.
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