期刊
NEUROSCIENCE RESEARCH
卷 120, 期 -, 页码 1-7出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2017.02.004
关键词
Fish; Teleost; Neurological disorders; Parkinson's disease; Neuroscience
资金
- JSPS KAKENHI [JP 14516799]
- Shimabara Science Promotion
- Takeda Science Foundation
- Japan Intractable Diseases Research Foundation
- GSK Japan Research Grant
- Yokoyama Foundation for Clinical Pharmacology
- Alexander von Humboldt Fellowship
- Grants-in-Aid for Scientific Research [15H05571, 17H05692, 16K14597] Funding Source: KAKEN
Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseases and psychiatric disorders. This review summarizes the advantages and disadvantages of using fish for neuropsychiatric research using primarily our own studies as examples. We discuss how fish belong to a class of vertebrates, are feasible for imaging, and include diverse species with multiple research possibilities yet to be discovered. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
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