期刊
NEUROSCIENCE LETTERS
卷 710, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2017.06.052
关键词
Amyothrophic lateral sclerosis; Motor neuron disease; Mitochondria; Neurodegeneration; Oxidative stress; Mitophagy; Axonal transport; Oxidative phosphorylation; Apoptosis
资金
- UK Medical Research Council (MRC) [MR/K005146/1, MR/M013251/1]
- Motor Neurone Disease Association Prize Studentship [DeVos/Oct13/870-892]
- UK Medical Research Council
- National Institute for Health Research
- Motor Neurone Disease Association
- EU
- NIHR
- MRC [MR/K005146/1, MR/M013251/1] Funding Source: UKRI
Mitochondria are unique organelles that are essential for a variety of cellular processes including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis. Mitochondrial dysfunction is a prevalent feature of many neurodegenerative diseases including motor neuron disorders such as amyotrophic lateral sclerosis (ALS). Disruption of mitochondrial structure, dynamics, bioenergetics and calcium buffering has been extensively reported in ALS patients and model systems and has been suggested to be directly involved in disease pathogenesis. Here we review the alterations in mitochondrial parameters in ALS and examine the common pathways to dysfunction. (C) 2017 The Authors. Published by Elsevier Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据