期刊
NEUROSCIENCE LETTERS
卷 653, 期 -, 页码 320-325出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2017.05.045
关键词
Consciousness; Complexity; Anesthesia; Ketamine; Propofol; Electroencephalogram
资金
- Ministry of Trade, Industry and Energy of Korea, Hannuri-daero, Sejong-si, Korea [10047988]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10047988] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ketamine and propofol have distinctively different molecular mechanisms of action and neurophysiological features, although both induce loss of consciousness. Therefore, identifying a common feature of ketamine- and propofol-induced unconsciousness would provide insight into the underlying mechanism of losing consciousness. In this study we search for a common feature by applying the concept of type-II complexity, and argue that neural complexity is essential for a brain to maintain consciousness. To test this hypothesis, we show that complexity is suppressed during loss of consciousness induced by ketamine or propofol. We analyzed the randomness (type-I complexity) and complexity (type-II complexity) of electroencephalogram (EEG) signals before and after bolus injection of ketamine or propofol. For the analysis, we use Mean Information Gain (MIG) and Fluctuation Complexity (FC), which are information theory-based measures that quantify disorder and complexity of dynamics respectively. Both ketamine and propofol reduced the complexity of the EEG signal, but ketamine increased the randomness of the signal and propofol decreased it. The finding supports our claim and suggests EEG complexity as a candidate for a consciousness indicator. (C) 2017 Elsevier B.V. All rights reserved.
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