期刊
NEUROSCIENCE LETTERS
卷 693, 期 -, 页码 54-57出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2017.09.049
关键词
Stress; Resilience; Medial Prefrontal Cortex; Serotonin; Anxiety
资金
- NIH [R01 MH050479, R21 MH106817]
- American Australian Association Fellowship
- NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation
In humans, many of the factors determining vulnerability and resilience to the impact of an adverse event revolve around coping factors. This mini-review focuses on the neural mechanisms by which coping reduces the impact of adverse events, as studied in an animal model, and discusses some of the challenges of linking neural circuit activity with stressor outcome. We highlight several approaches for probing circuit function with cell-type and pathway-specificity that overcome some of the limitations of traditional neuroscience techniques and will likely yield a more detailed and comprehensive understanding of how the brain regulates stress-responsive structures when coping behaviors are engaged.
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