期刊
NEUROSCIENCE LETTERS
卷 640, 期 -, 页码 70-75出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2017.01.008
关键词
Cardiac output; Cerebral blood flow; Early brain injury; Mouse model; Milrinone; Delayed cerebral ischemia; Subarachnoid hemorrhage
资金
- Japan Society for the Promotion of Science [15K10966]
- Life Science Foundation of Japan
- Cooperative Research Project Program of Joint Usage/Research Center at the IDAC
- Tohoku University
- Grants-in-Aid for Scientific Research [15K10966] Funding Source: KAKEN
Background and purpose: Acute cerebral hypoperfusion following subarachnoid hemorrhage (SAH) is highly related to the pathogenesis of delayed cerebral ischemia (DCI), but the therapeutic option is poorly available. This study aimed to clarify the effect of milrinone (MIL) on cerebral blood flow (CBF) and related outcomes after experimental SAH. Methods: Twenty-seven male C57BL/6 mice were assigned to either sham surgery (SAH-sham; n= 6), SAH induced by endovascular perforation (control; n = 10), or SAH followed by cardiac support with intravenous MIL (n= 11) performed 1.5-h after SAH induction. CBF, neurobehavioral function, occurrence of DCI were assessed by MR-continuous arterial spin labeling, daily neurological score testing, and diffusion and T2-weighted MR images on days 1 and 3, respectively. Results: Initial global CBF depression was notable in mice of control and MIL groups as compared to the SAH-sham group (P<0.05). MIL raised CBF in a dose-dependent manner (P<0.001), resulted in lower incidence of DCI (P=0.008) and better recovery from neurobehavioral decline than control (P<0.001). The CBF values on day 1 predicted DCI with a cut-off of 42.5 ml/100 g/min (82% specificity and 83% sensitivity), which was greater in mice treated with MIL than those of control (51.7 versus 37.6 ml/100 g/min; P<0.001). Conclusion: MIL improves post-SAH acute hypoperfusion that can lead to the prevention of DCI and functional worsening, acting as a neurocardiac protective agent against EBI. (C) 2017 Elsevier B.V. All rights reserved.
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