期刊
NEUROSCIENCE LETTERS
卷 636, 期 -, 页码 177-183出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2016.11.001
关键词
Acupuncture; Asthma; Inflammation; Immunologic function; HPA axis
资金
- National Natural Science Program of China [81403476, 81573758]
- Shanghai health and family planning commission program for traditional Chinese medicine [2016JP001]
- Development Project of Shanghai Peak Disciplines-Integrated Chinese and Western Medicine
Asthma is a complex inflammatory disease of the airways and acupuncture is one of the effective therapies widely used to treat asthma in China. The aim of the study was to evaluate the regulatory role of acupuncture in airway inflammation and the hypothalamic-pituitary-adrenal (HPA) axis activity in OVA-induced murine asthma model. Our results demonstrated that acupuncture was effective in suppression of AHR, inhibition of total leukocyte, neutrophil, lymphocyte and eosinophil counts in BALF, attenuation of airway inflammation and TNF-alpha, IL-1 beta, IL-5 and eotaxin secretion. Furthermore, the HPA axis activity was also regulated by acupuncture, which included promotion of adrenocorticotropic hormone and cortisol secretion in the plasma. Our findings revealed that acupuncture could attenuate airway inflammation and regulate HPA axis and immunologic function in the OVA-induced murine asthma model, which may provide support to better understand the contribution of acupuncture to the regulation of airway inflammation and HPA axis activity in asthma. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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