期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 73, 期 -, 页码 191-218出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2016.12.013
关键词
Stress; Psychosis; Clinical high-risk for psychosis; Schizophrenia; Neural diathesis-stress model; Hypothalamus-pituitary-adrenal axis; Cortisol; Brain; Hippocampus; Pituitary; Stress vulnerability
资金
- National Institutes of Mental Health [NIMH UO1MH081988]
- NARSAD Young Investigator award
- Golden Family foundation
- Canadian Institutes of Health Research [CIHR125913]
- Sir Henry Wellcome Postdoctoral Fellowship [107395/Z/15/Z]
- Waterloo Foundation Child Development Fund [164/1719]
- University of Oslo
- Scandinavian College of Neuropsychopharmacology (SCNP) Young Scientist Award
- South-Eastern Norway Health Authority [2013088]
- NARSAD Young Investigator Grant [22388]
- Wellcome Trust [107395/Z/15/Z] Funding Source: Wellcome Trust
Over the past decade, our understanding of the role of stress in serious mental illness has become more sophisticated. In this paper, we revisit the neural diathesis-stress model of schizophrenia that was initially proposed in 1997 and updated in 2008. In light of cumulative research findings, we must now encompass evidence on the premorbid periods of psychosis, and our more nuanced understanding of hypothalamic-pituitary-adrenal (HPA) axis function and its association with neurodevelopmental, epigenetic, neurotransmitter, and inflammatory processes, as well as brain structure and function. Giving consideration to the methodological complexities that have become more apparent as research in this area has burgeoned, the various indices of HPA axis function, and the different stages of illness, we review relevant research published since the 2008 update of the model. We conclude by proposing an extended neural diathesis-stress model that addresses the broader neurobiological context of stress psychobiology in psychosis progression. Implications of this model for best practice, with regards to both future research and treatment strategies, are discussed. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据