期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 76, 期 -, 页码 336-362出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2016.06.002
关键词
Phospholipids; Fatty acids; Sphingolipids; Endocannabinoids; Depression; Anxiety; Schizophrenia; Addiction
资金
- German National Science Foundation (Deutsche Forschungsgemeinschaft) [DFG KO 947/15-1, GU 335/29-1, MU 2789/8-1, FOR926 (SCHN 958/4-1), SP9]
- Annika Liese Price
- Interdisciplinary Center for Clinical Research Erlangen [E13]
- Austrian Science Fund (FWF) [E13] Funding Source: Austrian Science Fund (FWF)
Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable proportion of the human population and severely compromise quality of life. Therefore, measures to prevent the manifestation, and treatments to ameliorate the symptoms, of these disorders are in high demand. Brain lipids determine the localization and function of proteins in the cell membrane of neurons. Lipids may also act as neurotransmitters or other signalling molecules. The lipid composition of the brain can be influenced by nutrition, environmental factors, and by behavioural activity. Thus, lipids represent a target for preventive medicine of psychiatric disorders. Here we review how brain lipids contribute to normal behaviour and to major psychiatric disorders with the focus on phospholipids/fatty acids, sphingolipids, and endocannabinoids. Accumulating evidence suggests a crucial role for membrane forming and signalling lipids in the brain in the etiopathologies of depression, bipolar disorders, schizophrenia, and drug addiction. Lipids also represent potential preventive interventions for these psychiatric disorders by either targeted dietary supplementation or pharmacological manipulation of lipid regulating enzymes. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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