期刊
NEUROSCIENCE
卷 343, 期 -, 页码 229-239出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2016.12.003
关键词
anxiety; working memory; cortisol; biomarker; neurodevelopmental disorder
资金
- Ichiro Kanahara Foundation for the Promotion of Medical Sciences and Medical Care
- Kyoto University
- Institute of Seizon & Life Sciences, Center of Developmental Education and Research
- Future Development Funding Program of Kyoto University Research Coordination
- Grants-in-Aid for Scientific Research [16K14824, 16K12446, 26640044, 14J00317] Funding Source: KAKEN
Extensive studies have reported cognitive abnormalities in neurodevelopmental disorders, such as autism spectrum disorder (ASD). Another line of evidence suggests that stress also affects cognitive functions. In this study, we investigated whether there were associations between stress hormones and cognitive functions in ASD and typically developing (TD) children. Cognitive functions in ASD and TD children were evaluated with a battery of psychological tests for working memory, behavioral flexibility, and social cognition for emotional assessments of others. ASD children exhibited higher hair and salivary cortisol, which reflects chronic and acute stress hormone levels of subjects, respectively, than TD children. Autism-spectrum quotient (AQ) was positively correlated with hair cortisol and the scores of Spence Children's Anxiety Scale in ASD children. In addition, a negative correlation was present between spatial working memory performance and hair cortisol in ASD, but not in TD, children. These results suggest that chronic stress hormone elevation may have relationships with some aspects of cognitive dysfunction in ASD subjects. (C) 2016 The Author(s). Published by Elsevier Ltd on behalf of IBRO.
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