期刊
NEURORADIOLOGY
卷 59, 期 11, 页码 1133-1142出版社
SPRINGER
DOI: 10.1007/s00234-017-1912-1
关键词
HIV-associated neurocognitive disorders; Motor deficit; Multimodal MRI imaging; Hand movement task; Insula cortex
资金
- Beijing Municipal Administration of Hospitals Incubating Program [PX2016036]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding [ZYLX201511]
- National Nature Science Foundation of China [81571634]
- National Science Foundation of China [81371537, 91432301]
- Major State Basic Research Development Program of China (973 Program) [2013CB733803]
- Fundamental Research Funds for the Central Universities of China [WK2070000033]
It is generally believed that HIV infection could cause HIV-associated neurocognitive disorders (HAND) across a broad range of functional domains. Some of the most common findings are deficits in motor control. However, to date no neuroimaging studies have evaluated basic motor control in HIV-infected patients using a multimodal approach. In this study, we utilized high-resolution structural imaging and task-state functional magnetic resonance imaging (fMRI) to assess brain structure and motor function in a homogeneous cohort of HIV-infected patients. We found that HIV-infected patients had significantly reduced gray matter (GM) volume in cortical regions, which are involved in motor control, including the bilateral posterior insula cortex, premotor cortex, and supramarginal gyrus. Increased activation in bilateral posterior insula cortices was also demonstrated by patients during hand movement tasks compared with healthy controls. More importantly, the reduced GM in bilateral posterior insula cortices was spatially coincident with abnormal brain activation in HIV-infected patients. In addition, the results of partial correlation analysis indicated that GM reduction in bilateral posterior insula cortices and premotor cortices was significantly correlated with immune system deterioration. This study is the first to demonstrate spatially coincident GM reduction and abnormal activation during motor performance in HIV-infected patients. Although it remains unknown whether the brain deficits can be recovered, our findings may yield new insights into neurologic injury underlying motor dysfunction in HAND.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据