期刊
NEURORADIOLOGY
卷 59, 期 3, 页码 247-253出版社
SPRINGER
DOI: 10.1007/s00234-017-1796-0
关键词
Contralateral C7 nerve transfer; Brachial plexus avulsion injury; Functional connectivity; Resting state; Cerebral plasticity
资金
- National Natural Science Foundation of China [81,271,558]
- Beijing Natural Science Foundation [7,132,061]
- Beijing Bureau of 215 Program [2013-3-033, 2009-02-03]
Introduction The purpose of this study is to assess the functional connectivity of the motor cortical network in patients with brachial plexus avulsion injury (BPAI) after contralateral C7 nerve transfer, using resting-state functional magnetic resonance imaging (RS-fMRI). Methods Twelve patients with total brachial plexus root avulsion underwent RS-fMRI after contralateral C7 nerve transfer. Seventeen healthy volunteers were also included in this fMRI study as controls. The hand motor seed regions were defined as region of interests in the bilateral hemispheres. The seed-based functional connectivity was calculated in all the subjects. Differences in functional connectivity of the motor cortical network between patients and healthy controls were compared. Results The inter-hemispheric functional connectivity of the M1 areas was increased in patients with BPAI compared with the controls. The inter-hemispheric functional connectivity between the supplementary motor areas was reduced bilaterally. Conclusions The resting-state inter-hemispheric functional connectivity of the bilateral M1 areas is altered in patients after contralateral C7 nerve transfer, suggesting a functional reorganization of cerebral cortex.
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