4.2 Article

Stability indicating HPLC method for simultaneous quantification of sildenafil citrate and dapoxetine hydrochloride in Pharmaceutical products

期刊

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 31, 期 6, 页码 2515-2522

出版社

UNIV KARACHI

关键词

Dapoxetine HCl; degradation product; sildenafil citrate; simultaneous quantification; stability indicating HPLC method; stress degradation study

向作者/读者索取更多资源

A stability-indicating HPLC-UV method for the simultaneous determination of sildenafil citrate and dapoxetine hydrochloride in solution and tablet was developed. The mobile phase was comprised of acetonitrile and 0.2M ammonium acetate buffer. The analyte was eluted at 3.392min and 7.255min for sildenafil citrate and dapoxetine HCl respectively using gradient system at a flow rate of 1.5mL/min. The theoretical plates count was>2000, tailing factor <1.30, capacity factor 3.19-7.58 and peak asymmetry factor <1.08.The method was linear from 5-180 and 1-40 mu g/mL with a correlation coefficient of 0.9999 and 0.9994 for sildenafil citrate and dapoxetine HCl respectively. The drug solution was stable at ambient room temperature (26 degrees C) for 48hours.Both drugs were found susceptible to oxidation and the drug content dropped slightly in acid and alkali condition but stable under UV light and heat. No interference from tablet excipients and degradation products was found.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据