期刊
FRONTIERS IN SYNAPTIC NEUROSCIENCE
卷 10, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fnsyn.2018.00034
关键词
AMPAR; NMDAR; neocortex; hippocampus; parvalbumin; somatostatin; interneuron; synapse-type-specific plasticity
资金
- CFI [LOF 28331]
- CIHR [OG 126137, NIA 288936]
- FRSQ [CB 254033]
- NSERC [DG 418546-2, DG 2017-04730, DAS 2017-507818]
- MRC [MR/J002976/1, MR/J012998/1]
- MRC [MR/J002976/1, MR/J012998/1] Funding Source: UKRI
Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocortex. For example, CP-AMPARs are found at connections from pyramidal cells (PCs) to basket cells (BCs), but not to Martinotti cells (MCs). This synapse type-specific expression of CP-AMPARs suggests that synaptic dynamics as well as learning rules are differentially implemented in local circuits and has important implications not just in health but also in disease states such as epilepsy.
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