期刊
NEUROPSYCHOLOGICAL REHABILITATION
卷 29, 期 3, 页码 339-360出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/09602011.2017.1301262
关键词
Spatial neglect; real-time functional magnetic resonance imaging; neurofeedback; self-regulation; visual cortex
资金
- Fondation Leenaards
- Swiss Nartional Science Foundation [166704]
- BRIDGE Marie Curie FP7 Fellowship from the European Union Seventh Framework Programme [267171, FP7/2007-2013]
- Ambizone
- Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung [PZ00P3-131932, BSSG10_155915]
- Societe Academique de Geneve [Foremane Fund]
- Swiss National Science Foundation (SNF) [PZ00P3_131932] Funding Source: Swiss National Science Foundation (SNF)
Hemineglect is common after right parietal stroke, characterised by impaired awareness for stimuli in left visual space, with suppressed neural activity in the right visual cortex due to losses in top-down attention signals. Here we sought to assess whether hemineglect patients are able to up-regulate their right visual cortex activity using auditory real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback. We also examined any effect of this training procedure on neglect severity. Two different neurofeedback methods were used. A first group of six patients was trained to up-regulate their right visual cortex activity and a second group of three patients was trained to control interhemispheric balance between their right and left visual cortices. Over three sessions, we found that the first group successfully learned to control visual cortex activity and showed mild reduction in neglect severity, whereas the second group failed to control the feedback and showed no benefit. Whole brain analysis further indicated that successful up-regulation was associated with a recruitment of bilateral fronto-parietal areas. These findings provide a proof of concept that rt-fMRI neurofeedback may offer a new approach to the rehabilitation of hemineglect symptoms, but further studies are needed to identify effective regulation protocols and determine any reliable impact on clinical symptoms.
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