期刊
APL BIOENGINEERING
卷 2, 期 1, 页码 -出版社
AIP Publishing
DOI: 10.1063/1.5018165
关键词
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资金
- Nuclear Regulatory Commission Fellowship [NRC-HQ-84-15-G-0036]
- Canada Foundation for Innovation [25413]
Targeted radiotherapies maximize cytotoxicity to cancer cells. In this work, we describe the synthesis, characterization, and biodistribution of antibody conjugated gold-coated lanthanide phosphate nanoparticles containing Lu-177. Lu-[177]Lu-0.5 Gd-0.5(PO4)@Au@PEG(800)@Ab nanoparticles combine the radiation resistance of crystalline lanthanide phosphate for stability, the magnetic properties of gadolinium for facile separations, and a gold coating that can be readily functionalized for the attachment of targeting moieties. In contrast to current targeted radiotherapeutic pharmaceuticals, the nanoparticle-antibody conjugate can target and deliver multiple beta radiations to a single biologically relevant receptor. Up to 95% of the injected dose was delivered to the lungs using the monoclonal antibody mAb-201b to target the nanoparticles to thrombomodulin receptors. The 208 keV gamma ray from Lu-177 decay (11%) can be used for SPECT imaging of the radiotherapeutic agent, while the moderate energy beta emitted in the decay can be highly effective in treating metastatic disease. (C) 2017 Author(s).
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