期刊
NEURON
卷 96, 期 4, 页码 871-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2017.09.052
关键词
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资金
- Medical Research Council
- European Research Council
- Edmond J. Safra Foundation
- Royal Society
- Wellcome Trust
- Novartis Research Foundation
- Swiss National Science Foundation
- MRC [G0900499] Funding Source: UKRI
- Medical Research Council [G0900499] Funding Source: researchfish
Synaptic scaling is a key homeostatic plasticity mechanismand is thought to be involved in the regulation of cortical activity levels. Here we investigated the spatial scale of homeostatic changes in spine size following sensory deprivation in a subset of inhibitory (layer 2/3 GAD65-positive) and excitatory (layer 5 Thy1-positive) neurons in mouse visual cortex. Using repeated in vivo two-photon imaging, we find that increases in spine size are tumor necrosis factor alpha (TNF-alpha) dependent and thus are likely associated with synaptic scaling. Rather than occurring at all spines, the observed increases in spine size are spatially localized to a subset of dendritic branches and are correlated with the degree of recent local spine loss within that branch. Using simulations, we show that such a compartmentalized form of synaptic scaling has computational benefits over cell-wide scaling for information processing within the cell.
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