期刊
NEURON
卷 95, 期 3, 页码 639-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2017.06.028
关键词
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资金
- European Research Council [ERC-2012-StG 310021]
- JAE-Pre fellowship (CSIC)
- King's College London
- Medical Research Council [MR/N026063/1] Funding Source: researchfish
- MRC [MR/N026063/1] Funding Source: UKRI
Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.
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