期刊
RSC ADVANCES
卷 8, 期 73, 页码 41795-41809出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ra07100d
关键词
-
资金
- Ferdowsi University of Mashhad [3/39699-1394/11/11]
- Buali Research Institute
- Tulane University
The syntheses of a new set of metal complexes MoO2L(CH3OH), VOL(CH3O)(CH3OH), , , SnLCl2 and SnLI2 with a new ligand (L = (2,2(disulfanediylbis((ethylthio)methylene)bis(hydrazin-2-yl-1-ylidene)bis(methanylylidene)) diphenol; L = S-ethyl-3-(2-hydroxyphenyl)methylenedithiocarbazate are described along with characterization by elemental analysis, mass spectrometry, spectroscopic (IR, H-1- and C-13-NMR) and TGA techniques. The crystal structures of compounds were determined by single crystal X-ray diffraction analysis and compared to powder X-ray diffraction (PXRD) patterns of the nano complexes obtained using ultrasonic methods. The PXRD results indicate that the compounds synthesized by ultrasonic methods have high crystallinity. The compounds were evaluated in an in vitro cytotoxicity study with two human cancer cell lines. The results of this study revealed that all complexes exhibit good cytotoxic activity when compared to the clinical drug, cisplatin. Interaction of the samples with human serum albumin (HSA) was investigated using fluorescence spectrophotometric methods and the Stern-Volmer quenching constant (K-SV) and free energy changes (G) were calculated at 298 K. The fluorescence quenching method is used to determine the number of binding sites (n) and association constants (K-a) at the same temperatures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据