期刊
DIAGNOSTICS
卷 8, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics8040070
关键词
selenium; selenoproteins; essential trace element; supplements; autoimmune thyroid diseases; Hashimoto's thyroiditis; Graves' disease
资金
- FEDER-Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020-Operational Program for Competitiveness and Internationalization (POCI), Portugal 2020
- Portuguese funds through FCT-Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Inovacao [POCI-01-0145-FEDER-007274]
- project Advancing cancer research: from basic acknowledgement to application [NORTE-01-0145-FEDER-000029]
- Projetos Estruturados de I & D & I - Norte 2020-Programa Operacional Regional do Norte
- Genzyme
Selenium is an essential micronutrient that is required for the synthesis of selenocysteine-containing selenoproteins, processing a wide range of health effects. It is known that the thyroid is one of the tissues that contain more selenium. The selenostasis maintenance seems to contribute to the prevention of immune mediated thyroid disorders. Prospective, observational studies, randomized, controlled studies evaluating selenium supplementation, and review articles that are available in Medline and PubMed have undergone scrutiny. The differences concerning methodology and results variability have been analyzed. Several authors support the idea of a potential efficacy of selenium (mainly selenomethionine) supplementation in reducing antithyroperoxidase antibody levels and improve thyroid ultrasound features. In mild Graves' orbitopathy, selenium supplementation has been associated with a decrease of the activity, as well as with quality of life improvement. Future research is necessary to clearly understand the selenium supplementation biologic effects while considering the basal selenium levels/biomarkers, selenoprotein gene polymorphisms that may be involved, underlying comorbidities and the major clinical outcomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据