期刊
EMBO REPORTS
卷 16, 期 2, 页码 213-220出版社
WILEY
DOI: 10.15252/embr.201439668
关键词
anandamide; CB1 receptor; extracellular vesicle; GABA release; microglia-neuron signaling
资金
- FISM [2012/R/17]
- Ministero dell'Istruzione, dell'Universita e della Ricerca [PRIN 2010-2011]
- POR-FESR Cariplo, Miner project [42708181]
Endocannabinoids primarily influence neuronal synaptic communication within the nervous system. To exert their function, endocannabinoids need to travel across the intercellular space. However, how hydrophobic endocannabinoids cross cell membranes and move extracellularly remains an unresolved problem. Here, we show that endocannabinoids are secreted through extracellular membrane vesicles produced by microglial cells. We demonstrate that microglial extracellular vesicles carry on their surface N-arachidonoylethanolamine (AEA), which is able to stimulate type-1 cannabinoid receptors (CB1), and inhibit presynaptic transmission, in target GABAergic neurons. This is the first demonstration of a functional role of extracellular vesicular transport of endocannabinoids.
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