期刊
EMBO REPORTS
卷 16, 期 12, 页码 1664-1672出版社
WILEY-BLACKWELL
DOI: 10.15252/embr.201540277
关键词
Drosophila; innate immunity; JAK/STAT signaling; muscles
资金
- Swedish Research Council
- Swedish Cancer Society
- Academy of Finland
- Sigrid Juselius Foundation
The role of JAK/STAT signaling in the cellular immune response of Drosophila is not well understood. Here, we show that parasitoid wasp infection activates JAK/STAT signaling in somatic muscles of the Drosophila larva, triggered by secretion of the cytokines Upd2 and Upd3 from circulating hemocytes. Deletion of upd2 or upd3, but not the related os (upd1) gene, reduced the cellular immune response, and suppression of the JAK/STAT pathway in muscle cells reduced the encapsulation of wasp eggs and the number of circulating lamellocyte effector cells. These results suggest that JAK/STAT signaling in muscles participates in a systemic immune defense against wasp infection.
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