期刊
NEUROLOGY
卷 89, 期 19, 页码 1944-1950出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000004630
关键词
-
资金
- Medtronic
Objective: To compare motor and nonmotor outcomes at 6 months of asleep deep brain stimulation (DBS) for Parkinson disease (PD) using intraoperative imaging guidance to confirm electrode placement vs awake DBS using microelectrode recording to confirm electrode placement. Methods: DBS candidates with PD referred to Oregon Health & Science University underwent asleep DBS with imaging guidance. Six-month outcomes were compared to those of patients who previously underwent awake DBS by the same surgeon and center. Assessments included an off-levodopa Unified Parkinson's Disease Rating Scale (UPDRS) II and III, the 39-item Parkinson's Disease Questionnaire, motor diaries, and speech fluency. Results: Thirty participants underwent asleep DBS and 39 underwent awake DBS. No difference was observed in improvement of UPDRS III (114.8 +/- 8.9 vs 117.6 +/- 12.3 points, p = 0.19) or UPDRS II (19.3 +/- 2.7 vs 17.4 +/- 5.8 points, p = 0.16). Improvement in on time without dyskinesia was superior in asleep DBS (16.4 +/- 3.0 h/d vs 11.7 +/- 1.2 h/d, p = 0.002). Quality of life scores improved in both groups (118.8 +/- 9.4 in awake, 18.9 +/- 11.5 in asleep). Improvement in summary index (p = 0.004) and subscores for cognition (p = 0.011) and communication (p, 0.001) were superior in asleep DBS. Speech outcomes were superior in asleep DBS, both in category (12.77 +/- 4.3 points vs 26.31 +/- 9.7 points (p = 0.0012) and phonemic fluency (11.0 +/- 8.2 points vs 25.5 +/- 9.6 points, p = 0.038). Conclusions: Asleep DBS for PD improved motor outcomes over 6 months on par with or better than awake DBS, was superior with regard to speech fluency and quality of life, and should be an option considered for all patients who are candidates for this treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据