期刊
TOXICS
卷 6, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/toxics6040069
关键词
phthalate; non-alcoholic beverages; liquid-liquid extraction; response surface methodology; GC-MS/MS
资金
- [VAST.TD.TP.03/16]
A novel method was developed for the sensitive, cheap and fast quantitation of 10 phthalates in non-alcoholic beverages by liquid-liquid extraction (LLE) combined with gas chromatography tandem mass spectrometry (GC-MS/MS). The best results were obtained when n-hexane was used as extraction solvent. A central composite design (CCD) was applied to select the most appreciated operating condition. The method performance was evaluated according to the SANTE/11945/2015 guidelines and was linear in the 0.1 to 200 mu g/L range for 10 phthalate compounds, with r(2) > 0.996 and individual residuals <15%. Repeatability (RSDr), within-laboratory reproducibility (RSDwr), and the trueness range were from 2.7 to 9.1%, from 3.4 to 14.3% and from 91.5 to 118.1%, respectively The limit of detection (LOD) was between 0.5 to 1.0 ng/L and the limit of quantitation (LOQ) was between 1.5 to 3.0 ng/L for all 10 compounds. The developed method was successfully applied to the analysis of non-alcoholic beverages.
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