期刊
出版社
IOP PUBLISHING LTD
DOI: 10.1088/1755-1315/108/4/042096
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资金
- Hubei Higher School Science and Technology Outstanding Young and Innovative Team Project [T201224]
- Wuhan Talents in Engineering Personnel for Scientific Research Projects on a Selective Basis
- Wuhan Huang He Yingcai (Health) plan
- opening project of key Laboratory of Optoelectronic Chemical Materials and Devices (Jianghan University), Ministry of Education [JDGD-201514]
Objective: This study was designed to investigate the effect of chromium (VI) on DNA-protein crosslinks (DPC) of SPC-A1 cells. Methods: We exposed SPC-A1 cells were cultured in 1640 medium and treated with the SPC-A1 cells in vitro to different concentrations of Hexavalent chromium Cr(VI) for 2h , the KC1-SDS precipitation assay were used to measure the DNA-protein cross-linking effect. Results: All the different concentrations of Cr(VI) could cause the increase of DPC coefficient in SPC-A1 cells. But this effect was not significant (P>0.05) at low concentrations; while in high concentration Cr(VI) induced SPC-A1 cells could produce DNA-protein cross-linking effect significantly (P<0.05). Conclusions: chromium (VI) could induce DNA-protein crosslink.
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