期刊
NEUROLOGICAL RESEARCH
卷 39, 期 11, 页码 965-972出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/01616412.2017.1368141
关键词
Early-onset Parkinson's disease; epigenetic; methylation; SNCA; PARK2
资金
- Scientific Research Projects Foundation of the Uludag University, Bursa, Turkey [KUAP(T)-2013/43]
Background and aim: The effect of epigenetic modifications in the genes related to Parkinson's disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson's disease (EOPD). Materials and methods: The promoter region methylation status of SNCA and PARK2 genes was evaluated by methylation specific-PCR (MSP) in 91 patients with EOPD and 52 healthy individuals. Results: The methylation of SNCA and PARK2 promoter regions were significantly lower in EOPD patients compared to the control group (P = 0.013 and P = 0.03, respectively). We also found that the methylation status of the SNCA might be associated with positive family history of PD (P = 0.042). Conclusion: Although it should be supported by further analysis, based on the results of the present study, the methylation status of SNCA and PARK2 genes might contribute to EOPD pathogenesis.
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