期刊
EMBO JOURNAL
卷 35, 期 2, 页码 162-175出版社
WILEY-BLACKWELL
DOI: 10.15252/embj.201592593
关键词
chromatin; H3K4 methylation; heat shock transcription factor; priming; transcriptional memory
资金
- Sofja-Kovalevskaja-Award (Alexander-von-Humboldt-Foundation)
- CRC 973 Project (DFG) [A2]
- Max-Planck-Society IMPRS Fellowship
In nature, plants often encounter chronic or recurring stressful conditions. Recent results indicate that plants can remember a past exposure to stress to be better prepared for a future stress incident. However, the molecular basis of this is poorly understood. Here, we report the involvement of chromatin modifications in the maintenance of acquired thermotolerance (heat stress [HS] memory). HS memory is associated with the accumulation of histone H3 lysine 4 di- and trimethylation at memory-related loci. This accumulation outlasts their transcriptional activity and marks them as recently transcriptionally active. High accumulation of H3K4 methylation is associated with hyper-induction of gene expression upon a recurring HS. This transcriptional memory and the sustained accumulation of H3K4 methylation depend on HSFA2, a transcription factor that is required for HS memory, but not initial heat responses. Interestingly, HSFA2 associates with memory-related loci transiently during the early stages following HS. In summary, we show that transcriptional memory after HS is associated with sustained H3K4 hyper-methylation and depends on a hit-and-run transcription factor, thus providing a molecular framework for HS memory.
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