期刊
NEUROIMAGE
卷 157, 期 -, 页码 34-44出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2017.05.060
关键词
FMRI; Resting state; Functional connectivity; Transcranial direct current stimulation; Network stimulation
资金
- Howard Hughes Medical Institute
- Parkinson's Disease Foundation
- Dystonia Medical Research Foundation
- NIH/National Institute of Neurological Disorders and Stroke [K23NS083741]
- Sidney R. Baer Jr. Foundation
- NIH [R21 NS082870, R01HD069776, R01NS073601, R21 MH099196, R21 NS085491, R21 HD07616]
- Harvard Catalyst \ The Harvard Clinical and Translational Science Center (NCRR)
- Harvard Catalyst \ The Harvard Clinical and Translational Science Center (NCATS NIH) [UL1 RR025758]
Scientists and clinicians have traditionally targeted single brain regions with stimulation to modulate brain function and disease. However, brain regions do not operate in isolation, but interact with other regions through networks. As such, stimulation of one region may impact and be impacted by other regions in its network. Here we test whether the effects of brain stimulation can be enhanced by simultaneously targeting a region and its network, identified with resting state functional connectivity MRI. Fifteen healthy participants received two types of transcranial direct current stimulation (tDCS): a traditional two-electrode montage targeting a single brain region (left primary motor cortex [M1]) and a novel eight-electrode montage targeting this region and its associated resting state network. As a control, 8 participants also received multifocal tDCS mismatched to this network. Network-targeted tDCS more than doubled the increase in left M1 excitability over time compared to traditional tDCS and the multifocal control. Modeling studies suggest these results are unlikely to be due to tDCS effects on left M1 itself, however it is impossible to completely exclude this possibility. It also remains unclear whether multifocal tDCS targeting a network selectively modulates this network and which regions within the network are most responsible for observed effects. Despite these limitations, network-targeted tDCS appears to be a promising approach for enhancing tDCS effects beyond traditional stimulation targeting a single brain region. Future work is needed to test whether these results extend to other resting state networks and enhance behavioral or therapeutic effects.
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