4.7 Article Proceedings Paper

Insights into brain microstructure from in vivo DW-MRS

期刊

NEUROIMAGE
卷 182, 期 -, 页码 97-116

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2017.11.028

关键词

Diffusion; Metabolites; Intracellular space; Cell structure; Tissue microstructure; Brain; H-1 magnetic resonance spectroscopy

资金

  1. Engineering and Physical Sciences Research Council [N018702]
  2. European Research Council under the European Union's Horizon 2020 research and innovation program [679058]
  3. European Research Council under the Marie Sklodowska-Curie grant [657366]
  4. European Research Council [336331 - INCELL]
  5. Marie Sklodowska-Curie grant [657366]
  6. Marie Curie Actions (MSCA) [657366] Funding Source: Marie Curie Actions (MSCA)
  7. EPSRC [EP/M020533/1, EP/N018702/1] Funding Source: UKRI

向作者/读者索取更多资源

Many developmental processes, such as plasticity and aging, or pathological processes such as neurological diseases are characterized by modulations of specific cellular types and their microstructures. Diffusion-weighted Magnetic Resonance Imaging (DW-MRI) is a powerful technique for probing microstructure, yet its information arises from the ubiquitous, non-specific water signal. By contrast, diffusion-weighted Magnetic Resonance Spectroscopy (DW-MRS) allows specific characterizations of tissues such as brain and muscle in vivo by quantifying the diffusion properties of MR-observable metabolites. Many brain metabolites are predominantly intracellular, and some of them are preferentially localized in specific brain cell populations, e.g., neurons and glia. Given the microstructural sensitivity of diffusion-encoding filters, investigation of metabolite diffusion properties using DW-MRS can thus provide exclusive cell and compartment-specific information. Furthermore, since many models and assumptions are used for quantification of water diffusion, metabolite diffusion may serve to generate a-priori information for model selection in DW-MRI. However, DW-MRS measurements are extremely challenging, from the acquisition to the accurate and correct analysis and quantification stages. In this review, we survey the state-of-the-art methods that have been developed for the robust acquisition, quantification and analysis of DW-MRS data and discuss the potential relevance of DW-MRS for elucidating brain microstructure in vivo. The review highlights that when accurate data on the diffusion of multiple metabolites is combined with accurate computational and geometrical modeling, DW-MRS can provide unique cell-specific information on the intracellular structure of brain tissue, in health and disease, which could serve as incentives for further application in vivo in human research and clinical MRI.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据